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Dr. Purl was assisting Col. Rudev Broga when the Shadowforce Alpha attacked the Empire State Hospital to kill him. Dr. Purl recovedere the dying body of Broga's bodyguard Cary Armstrong, and attempted to use Curt Connors' reptilian regeneration treatments on him[1].
As Purl began the procedure on Armstrong, the NYPD cut the power to the building, forcing Purl to perform CPR to restart the flatlining agent. With the procedure a success, Armstrong burst into the operating theater where the remaining members of Shadowforce were holding hostages[2].
After Ben Reilly became his lab assistant, Dr. Purl invited him at his party in Dix Hills, which was attacked by the Lizard[3].
Dr. Purl was once again attacked by the Lizard at the Empire State Hospital and went into a coma[4].

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