When Apocalypse started his plans for world domination, he captured four people who he saw as being good enough to be his Horseman and corrupted them. Spider-Man became the Horseman known as Pestilence.

Pestilence was one of the Horsemen Deadpool, Cannonball, and Siryn encountered in their alternate reality search for Cable.

And even though Pestilence was accompanied in the fight by Famine and Archangel, all three of them were defeated.[citation needed]


Seemingly those of Spider-Man of Earth-616, mutated and augmented by Apocalypse.



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