- Chief Examiner
- Doctor Doom (Victor von Doom)
- Blob (Fred Dukes)
- Circus of Crime
The Human Torch and the Thing must work together in order to rescue Alicia Masters from Dr. Doom's Latverian castle.
A tie-in comic was released along side the game.
Despite the title's claim that the game featured The Fantastic Four, only The Thing and The Human Torch are featured in the game.