Rosalie Octavius was the wife of Otto Octavius, as well as his lab partner. Peter Parker met Rosalie and Otto while they were working on their ill-fated nuclear fusion project, and he had dinner with her and Otto to discuss topics for a paper he had to write. There the couple gave Peter advice on how to woo Mary Jane Watson based on their personal experience: to use poetry (which ended up blundering).

Rosalie is known for being the only casualty of the nuclear fusion project that made Otto "Doc Ock". Her death was caused by shards of flying glass impaling her while she hid behind a pillar and screamed. Her body was later seen being removed.[1]

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