The Saint Agnes Orphanage was an orphanage in New York City. Daisy Johnson was discovered by a S.H.I.E.L.D. in China. Her entire village and most of the team were killed protecting her. Back in the United States of America, the remaining members started to be systematically eliminated. Fearing for the child's life, Agent Linda Avery, took her too Saint Agnes Orphanage, legally naming her "Mary Sue Poots".[1] S.H.I.E.L.D. had an arrangement with the orphanage to keep the girl safe by transferring her to different foster homes after certain periods of time. One foster home she liked belonged to the Brodys, but, as per the arrangement, she was not allowed to stay.[2]

Matt Murdock was also placed in the orphanage after the death of his father. Due to his condition, one of the nuns called for the help of Stick, who was able to train Matt.[3]

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