Scream was one of the five Life Foundation Symbiotes that were forcefully spawned from the Venom symbiote.
- Donna Diego was a mercenary hired by the Life Foundation. In order to fulfill her role as a superhuman officer for the corporation's future utopia, she was granted one of the 5 symbiotes forcibly spawned from the Venom symbiote.
- Patricia Robertson was a twenty-four year-old lieutenant and communications specialist in the US Army who was bounded to a Venom symbiote's clone before it merged to Venom. Years later Patricia was overwhelmed and bonded to the Scream symbiote, and the two succumbed to the dark god Knull 's control.
- Andi Benton was one of Flash Thompson's neighbors and students in Philadelphia. She was bound to the Mania symbiote and it's Hell-Mark. She had her symbiote stolen and later she was bonded to the Scream symbiote after Patricia sacrificed herself in order to protect Andi from Carnage.