The Scream symbiote was the symbiote of Donna Diego. While merged with Diego, it made her very aggressive and dangerous. Together, Diego and Scream were members of the Sinister Syndicate. When the members of J. Jonah Jameson's "Team Scoop" stumbled upon their lair, Scream stared at them, pointing them out when Electro heard them. After Electro failed to destroy them, Scream attempted to pounce on them. Doc Ock, however, held her back, claiming "Get away, they're mine!", as she helplessly attempted to claw at them. She hissed at them while they made their escape.

Scream was once more seen using the hair provided by the symbiote to tie Spider-Man to a pole, attempting to keep him from protecting Team Scoop. Spidey managed to escape and defeat her and her symbiote. She was later seen, along with the rest of the Syndicate, webbed up and captured.[1]


Seemingly those of the Scream symbiote of Earth-616

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