Si Ma and her colleague Nero were scientists who worked for Bio-Armor, a technological research firm contracted by the Stark Defense Corporation. Under the leadership of SDC's founder Howard Stark, Si Ma and Nero were instrumental in creating a bacterial body sheathe that would render an individual impervious to most conventional forms of injury.Howard Stark lost controlling interest in Stark Defense Corporation to his rival Zebediah Stane, but fortunately, Stane had no legal ownership over projects designed by Bio-Armor.

Following the birth of Howard's son Antonio, Si Ma contributed to the process that bonded the infant with the Bio-Armor technology. She continued to work for Howard Stark and served as the primary personal physician for young Antonio.[citation needed]

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