The team was assembled for a short period of time by Doctor Octopus, as part of his plan of revenge on Norman Osborn. Otto released Mister Negative, Electro, the Vulture, Rhino, and Scorpion to wreck havoc on Manhattan, as a form of destabilize the city's trust in Norman's rule.
Defeat by Spider-Man
Spider Man went around the city defeating both Electro and the Vulture in Hell's Kitchen, Rhino and Scorpion near the George Washington Bridge, Mister Negative was defeated on the Oscorp building on Upper West Side, and the last member, Doctor Octopus, was defeated on a epic battle atop Oscorp Tower.
- Apparently, Otto reverse-engineered Sable International tech to build the team's enhanced suits.
- 6 Sinister Six (Earth-1048) Members
- 2 Appearances of Sinister Six (Earth-1048)
- Minor Appearances of Sinister Six (Earth-1048)
- 1 Media Sinister Six (Earth-1048) was Mentioned in
- 2 Images that include Sinister Six (Earth-1048)
- Team Gallery: Sinister Six (Earth-1048)