When the Sinister Six started out, they were able to conquer their native Earth. Collecting the reality's Isotope-8, they were able to create a inter-dimensional portal. Utilizing inter-dimensional warships, they set out to conquer alternate worlds. During their travels, they recruited alternate versions of the original members and an army of henchmen. They finally met their match when they reached Earth-TRN461, who had created an inter-dimensional team of their worst enemy to combat them.
- The Amazing Spider-Man found that the Six have no data on his friends and family; however, House of M Green Goblin is his analog and Doctor Octopus, Green Goblin, Mysterio and Vulture already knew his identity.
- Steel Spider and Superior Spider-Man were considered possible recruits. Steel Spider never got the invite and Superior declined.
- 10 members of Sinister Six (Multiverse)
- 1 appearance(s) of Sinister Six (Multiverse)
- 7 image(s) of Sinister Six (Multiverse)
- 3 item(s) used/owned by Sinister Six (Multiverse)