Appearing in 1st story
- New Avengers
- Frog-Man (Eugene Patillo)
- Iron Fist (Danny Rand)
- Secretary-General Ban Ki-Moon (First appearance)
- New York City
Synopsis for 1st story
The Avengers respond to the emergency of the Spider-Island infestation with Ms. Marvel, Jessica Jones and Hawkeye (who is infected with the Spider-Virus and posseses Spider-Man's powers and spider-sense) watching over the United Nations Headquarters where members of ULTIMATUM led by Flag-Smasher planes to destroy the base with its leader but the heroes find out that ULTIMATUM thugs are also infected and have Spidey's powers.
Nearby, former Initiative hero Frog-Man watches the plans unfoil and enters into action much to the annoyance of The Avengers. When all the heroes enter, things turn complicated when the ULTIMATUM thugs overpower the heroes with Spider-Man's skills but Frog-Man's unexpected assistance becomes a hindrance to Flag-Smasher and they manage to save the city on time.
Meanwhile, Squirrel Girl babysits Luke Cage and Jessica's daughter Danielle but finds out that she's also infected with the Spider-Virus and has a hard time trying to keep her stable until eventually she ends up wrapped up in spider web.
SPIDER-ISLAND TIE IN! All of Manhattan has been transformed into an island of Spider-Men... and it's up to the Avengers to contain the chaos. But when a spider-powered Ultimatum attacks the United Nations, the Avengers are spread too thin... and must turn to the one man who can save them all: FROG-MAN. No, for real. We were just as surprised as you. PLUS! Squirrel Girl takes on the most unlikely foe of all!