In response to Molina's confusion about the fate of Doctor Octopus from the film Spider-Man 2, director Jon Watts told Molina, “In this universe, no one really dies.” Early conversations Molina and Watts had about Spider-Man: No Way Home had his character pick up from his death in Spider-Man 2. Digital de-aging effects will be used on Molina.
Additionally, Harry Holland, Tom's younger brother, will make a cameo appearance as a drug dealer.
Right after the release of Spider-Man: Far From Home, negotiations between Marvel Studios and Sony Pictures largely regarding the shares of the revenue of the Spider-Man films broke down, thus ending Sony's deal to have Spider-Man appear in the Marvel Cinematic Universe. Due to the fan backlash and Tom Holland's pleading with then-Disney CEO Bob Iger, negotiations were resumed a few weeks later. At the end of September 2019, the two companies announced that they'd continue their collaboration for a third Spider-Man film and another MCU movie where Spider-Man would appear.
Originally scheduled with the American release date of July 16, 2021, it was pushed back to November 5, 2021, then again to December 17, 2021, due to the COVID-19 pandemic.
Filming started on October 16 2020, in Queens.
The title of the film was revealed via Twitter by Sony on February 24, 2021.