Appearing in "The Return of Hydro-Man Part 2"
- Mary Jane Watson (clone) (Death)
- Hydro-Man (clone) (Death)
- Green Goblin (Only in flashback)
- Kingpin (Only in flashback)
- Hydro-Man (Only in flashback)
- Alistaire Smythe
- Dr. Miles Warren (Final appearance)
- Aunt May Parker (Final appearance)
- Anna Watson (Final appearance)
- Detective Terri Lee (Final appearance)
- Felicia Hardy / Black Cat
- J Jonah Jameson (Only in flashback)
- Punisher (Only in flashback)
- Madame Web
Synopsis for "The Return of Hydro-Man Part 2"
Mary Jane has been revealed to have newfound water-based powers like Hydro-Man. Spider-Man follows Hydro-Man to an underwater lab, where he discovers that a scientist, Miles Warren, has used his controversial cloning technology to create this new Hydro-Man. He is even more shocked to learn that Warren then used a sample of Mary Jane's hair and a drop from Hydro-Man to clone Mary Jane!
- No special notes.
- No trivia.