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Miguel O'Hara was a geneticist working for Alchemax while his boss Tyler Stone was working on genetically giving humans superpowers. After a test subject had died, Miguel confronted his boss and Stone offered him a drink, which was laced with a drug called Rapture that changed the user's DNA and made the user's life dependent on its continuous consumption. Stone intended to use it to blackmail Miguel, but Miguel had other ideas and returned to his lab at Alchemax to restore his DNA to its original constitution. However, this backfired when a jealous coworker switched the template DNA to an experimental DNA created in an attempt to replicate a superhero Spider-Man. Miguel was cured of the Rapture but in the process his DNA became fifty percent spider. Miguel soon realized that with his abilities and position in Alchemax, he could take down Tyler Stone and his Alchemax monopoly that held Nueva York ( New York of 2099) in tyranny.

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Spider-Man 2099 Comics