Following the Headmistress' passing, a group of her pupils attempted to use the demon Shiklah as a vessel for her soul. To this end, they lured Shiklah's husband Deadpool with the promise of a chimichanga-eating contest. Once they captured Deadpool, they planned to summon Shiklah using a ritual that would bring Deadpool's heartmate. To the girls' surprise, Deadpool's heartmate turned out to be Spider-Man. The students decided to continue with the resurrection ritual either way, and spread on the confused hero the ashes of Headmistress Soo, causing him to slowly become possessed by her soul. In an attempt to have the teenagers undo the spell, Spider-Man webbed them up.
The girls' plan concurred with the Leviathon invasion, so both Spider-Man and Deadpool's attention was diverted to the landing of a giant monster in Toronto. When Deadpool was temporarily swallowed by the monster and Spider-Man found himself starting to lose control of his body, he got Soo's pupils to help him defeat and subdue the monster.
Having taken control of Spider-Man's body, Soo encouraged her pupils to help her drown the beast in a lake nearby so once its soul escaped its body, they could feed on it. Soon after sinking the creature, Soo affected her students with an age regression hex so she could have the monster's soul entirely for her alone. However, the creature emerged from the water.
After Deadpool convinced Soo to help him defeat the monster, her strength faded out, causing her to leave Spider-Man's body. The age regession hex also worn off. Soo's pupils caught up with Spider-Man and Deadpool, and helped the latter find the body parts he had lost in battle.
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