Doctor Strange shared a similar history to his Earth-616 counter-part until Emma Frost did not alter the mind of Gwen Stacy when Peter Parker learned the truth about the House of M reality. This eventually caused Gwen to arrive on the main universe. Strange sensed something was wrong with the universe and eventually tracked Gwen down, he told her what was wrong and how she was the universal imbalance and the only way to restore the universe was for her to no longer exist. He began to cast a spell, but Gwen's fear caused her to teleport away. After Gwen witnessed the death of everything Peter loved, she attempted to kill herself but was saved by Peter, and the two embraced as reality faded. Whether this was caused by Doctor Strange or his fate after this is currently unknown.[1]

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