Little is known about Swiss Miss. During the retelling of Spider-Man's origin, Miss Arrow, one of the musical narrators, spontaneously adds Swiss Miss to the line-up of the original Sinister Six, feeling that the team could use a "woman's touch".

The Green Goblin mutated a female scientist and transformed her into Swiss Miss. Swiss Miss later fought Spider-Man, (alongside Electro), as part of the Sinister Six. When she attempted to stab Spider-Man, Spider-Man leaped out of the way; which caused Swiss Miss to stab Electro and electrocute herself. Because of this, both Swiss Miss and Electro were defeated.

So far this is the only appearance of a Swiss Miss in a version of Spider-Man.

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