In a new article from USA Today announcing the newest Marvel OGN, Spider-Man: Family Business, it has been revealed that Peter Parker may have a sister!
Written by Mark Waid (co-written by James Robinson) and painted by Gabriele Dell'otto, Family Business tells the story of The Kingpin and his newly organized crime syndicate deciding to expand his criminal empire - globally. Peter finds himself under attack when a mysterious woman in a convertible arrives, declaring herself as his long-lost sister, Teresa Parker.
Also detailed in the new OGN, will be more history into Richard and Mary Parker and their tragic deaths with appearances by classic Spidey villains Rhino, Cyclone, and more.
Spider-Man: Family Business will be released in 2014.
EDIT: This takes place BEFORE the events in Amazing Spider-Man #700