I believe that Spider-Man's deal with Mephisto from One More Day is starting to crumble. Ever since Ghost Rider usurped Mephisto from his throne during the Damnation event, the deal is now gradually falling apart. That would explain a whole lot of things: Peter and Mary-Jane getting back together, Aunt May diagnosed with cancer, Harry becoming the evil demon Kindred with no explanation on how or why, Peter revealing his identity to J. Jonah Jameson and then Black Cat. It's as if Spider-Man's deal with the devil himself is starting to fall down on him really hard. I can only imagine what could possible come next for Spidey: Debra Whitman returning after her last appearance, Liz attempting to get revenge again, the mysterious sniper that shot Jake Martino reveal himself. The possibilites are overwhelming!