Weapon V was a codename for the fifth installment of the Weapon Plus Program, a top-secret supersoldier initiative. In 1965, an alien dragon made of living darkness was discovered frozen in a glacier by S.H.I.E.L.D. and codenamed Grendel. A team led by Nick Fury began experimenting with samples extracted from the Grendel and discovered they could be bonded to host organisms to create predatory monsters. Under pressure from the government to produce a replacement for the M.I.A. Captain America, Fury initiated a symbiote-supersoldier program in 1966 and field-tested it during the Vietnam War, to disastrous results. After the Sym-Soldier Program was declared a failure by S.H.I.E.L.D. and officially shut down, Weapon Plus surreptitiously took over and rebranded the initiative as "Weapon V" or "Project Venom" - appropriating personnel and research while crediting Fury as the founder.
Over the next few decades, Weapon V closely monitored subsequent U.S. Government-initiated offshoots of the Sym-Soldier Program such as Project Rebirth 2.0 and the Mercury Team. Learning from their successes and failures, Weapon V determined that the Sym-Soldier prototypes had been corrupted by the symbiote hive-mind and were able to create suits of bio-armor virally-altered to be free of the contamination.
Seven months after the Grendel symbiote-dragon reawakened and attacked Manhattan, the Weapon V Headquarters was attacked by the symbiote-augmented serial killer Carnage, who had bonded to a sample of the Grendel symbiote and been greatly empowered by its connection to Knull, the dark elder god who had created the symbiotes billions of years ago. Most of the personnel were slaughtered, but Mars Team - a strikeforce led by Robert Urquhart - managed to escape and plot revenge by forcibly enlisting the aid of fellow Weapon Plus experiment Weapon H; however, Weapon V's head of research and development, Dr. Andrew Breen, went insane and sabotaged Mars Team's fight against Carnage, enabling him to kill them all.
Equipment: Weapon V's operatives are bonded to suits of symbiote bio-armor engineered from samples of the Grendel symbiote-dragon, virally altered to be disconnected from the corrupting influence of the symbiote hive-mind.
Weapons: In addition to wielding military ordinance, Weapon V operatives can use their symbiotes to manifest claws, fangs, spikes, tendrils, and blades.
- In Wolverine & Captain America: Weapon Plus #1, Nick Fury is named as the lead of Weapon V in reference to his role as the head of the Sym-Soldier Program. This was retconned in Absolute Carnage: Weapon Plus #1, which established that Weapon V was a secret offshoot of the Sym-Soldier Program established by Weapon Plus after S.H.I.E.L.D. shut it down.
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