Appearing in "The Hunt for Sabretooth: Part 1"
- Weapon X Program
- Director Malcolm Colcord (Origin revealed)
- Agent Garrison Kane
- Sauron (Karl Lykos)
- Marrow (Sarah)
- Wild Child (Kyle Gibney)
- Aurora (Jeanne-Marie Beaubier)
- Washout (John Lopez)
- Mesmero (Vincent)
- Gemini / Box (Madison Jeffries) (Last apparence as Gemini) (Leaves Zodiac and joins Weapon X)
- Agent Brent Jackson
- Zodiac (Last appearance) (Disbands)
- Sabretooth (Victor Creed) (Behind the scenes)
- Andrew Potts (Dream) (Only appearance; dies)
- Weapon X (Logan) (Dream)
- X-Men (Dream)
- Brotherhood of Mutants (Dream)
- Juggernaut (Cain Marko) (Dream)
- Apocalypse (En Sabah Nur) (Dream)
- X-Force (Dream)
- Deadpool (Wade Wilson) (Dream)
- Mutant Liberation Front (On-screen)
- God (Yahweh) (Invoked)
Races and Species:
- Adamantium (On Weapon X's claws) (Dream)
- Cyclops' Visor (Dream)
- Deadpool's Suit (Dream)
- Box Armor Model 3
Synopsis for "The Hunt for Sabretooth: Part 1"
Weapon X fights the Zodiac, apparently killing them all, and The Director is proud. Members of the team are introduced including: Kane, Sauron, Mesmero, Aurora, Jeffries, and Marrow. Sabretooth had previously destroyed all the teleportation gates of the Weapon X facilities, and now kills Locus just to spite them, as they could have used her teleporting powers. The Director then forces Jeffries to use his powers to start on his plans of a mutant concentration camp. He then says it will be just their secret..
- This cover is an homage to Wolverine #1.