From time to time, Daredevil was seen running along an abandoned stretch of the West Side elevated highway.
The Kingpin's hideout was located in a sub-cellar at Fiftieh Street and Eleventh Avenue.
The Scarlet Witch drove down the West Side Highway into Manhattan to reach the private warehouse the Avengers used as a garage.
Mister Hyde owned a warehouse on the West Side Highway, where he processed the Mutant Growth Hormone.
Hyde was eventually defeated by the Young Avengers.
A few times later, Daredevil was caught battling an echo of Klaw on the West Side Highway.
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