In the three decades that the Conquistador was at sea -- assuming it was inhabited -- the people inside it would have lived through six thousand years. 
Appearing in "Supernovas: Part 4 of 6"
Featured Characters:
Supporting Characters:
- Lady Mastermind (Regan Wyngarde) (Comatose or unconscious)
- Sabretooth (Victor Creed) (Main story and flashback)
Antagonists:
- Children of the Vault (Main story and flashback) (First appearance historically)
- Serafina / "Sarah Guthrie" (Main story and flashback)
- Fuego (Main story and flashback)
- Sangre (Main story and flashback)
- Perro (Main story and flashback)
- Aguja (Only in flashback)
- Several unidentified others (Only in flashback)
Other Characters:
- Pasco (First appearance; dies) (Only in flashback)
- Unus the Untouchable (Gunther Bain) (Mentioned)
- Doctor Casales (First appearance; dies) (Only in flashback)
- Paul Brunner (First appearance; corpse) (Possessed by Ev Teel Urizen) (Unnamed)
- Ev Teel Urizen (First appearance) (Possesses Paul Brunner's corpse) (Unnamed)
- O*N*E
- Unnamed agents
- God (Mentioned)
- Agostini (Mentioned)
- Rosado (Mentioned)
- Bella Pagan (Only on screen as a static image or video record)
- Northstar (Jean-Paul Beaubier) (Mentioned)
- Aurora (Jeanne-Marie Beaubier) (Mentioned)
Races and Species:
- Mutants (Main story and flashback)
- Post-Humans (Main story and flashback)
- Cyborgs
- Humans (Main story and flashback)
- Mummudrai (Behind the scenes)
Locations:
- Earth
- North America
- United States of America
- Mexico (Mentioned)
- Nogales, Sonora (Mentioned)
- Panama, Central America (Mentioned)
- South America (Main story and flashback)
- Pacific Ocean (Only in flashback)
- North America
Items:
- X-Uniforms
- Techno-Organic Virus
- Cyclops' Visor
- Adamantium (on Wolverine's claws and body)
Vehicles:
- El Conquistador (Name revealed) (Main story and flashback)
- The Vault (Main story and flashback)
Events:
- M-Day (Only in flashback)
Synopsis for "Supernovas: Part 4 of 6"
- Synopsis not yet written
Notes
- This issue confirms that M-Day occurred on November 2nd.